A recent study indicates that people who discontinue popular slimming jabs like semaglutide or tirzepatide can put back on reduced body mass far faster than those who stop traditional diet and exercise plans.
Findings released in a prominent medical journal points out that while overweight individuals can lose a large proportion of their total mass while using the jabs, the weight returns at an estimated rate of nearly a kilo each month upon discontinuation.
"Users buying such treatments must be aware of the danger of quick weight regain when the medication is stopped," stated expert Dr. Susan Jebb.
That rate of recovery implies a return to starting mass within about a year and a half.
Comparing Approaches
The study, which examined 37 of studies involving thousands of patients, contrasted the effects of the injectable medications with conventional dieting.
Scientists point out that individuals who lose weight through dieting usually have a slower weight regain—approximately 0.1 kg a month—after stopping.
Understanding the Fast Rebound
Experts believe the mode of action of the drugs is key to understanding the amplified rebound.
These medications imitate a natural hormone called GLP-1, which moderates feelings of fullness.
"Long-term administration of the hormone concentrations several times higher than the body's typical production might result in the system to generate a reduced amount of its own natural hormone, and could diminish sensitivity to its actions," said Dr. Adam Collins, a nutrition expert.
"Stopping of this GLP-1 'fix' means hunger is uncontrolled, making excessive eating far more likely."
A Lifelong Issue?
The NHS suggest the jabs for individuals with obesity-related medical conditions, alongside recommended diet and exercise modifications.
Professionals say that, given the high risk of relapse, the therapy should be considered long-term.
This view is reinforced by drug manufacturers, who state that the findings "emphasize the persistent nature of excess weight," akin to managing conditions like hypertension.
User Experiences
Users who have discontinued the jabs describe a intense return of appetite.
"I experienced something that goes on and you're instantly extremely hungry," recalled one woman.
This difficulty is exacerbated if patients have not adopted permanent lifestyle or habit changes during treatment.
Significant Interest
Figures suggest that millions of people in the UK have tried these injections in the last 12 months, with demand being substantial.
- Use is more common among women than men.
- The middle-aged demographic shows the greatest usage rates.
- Many obtain the medications through private prescriptions rather than public health services.
In conclusion, experts caution that while the jabs are effective agents for shedding pounds, they are not a standalone solution and long-term success hinges on integrated behavioural changes.
